Current Concepts in the Management of Osteoporosis:
Highlights From the 8th International Symposium on Osteoporosis (ISO)
Release date: July 2009
Expiration date: July 30, 2010
Estimated time to complete activity: 1 hour
Sponsored by
Support for this activity has been provided through an educational donation from

Activity Overview
Osteoporosis is defined by the presence of either a fragility fracture or by a bone mineral density (BMD) T-score ≤-2.5 standard deviations below the BMD value for the standard reference population. Primary osteoporosis is caused by a lack of estrogen in women and a lack of testosterone in men. Secondary osteoporosis is caused by certain medical conditions or medications. Bone fracture is the most significant consequence of osteoporosis; pharmacologic agents are often used to reduce the risk of fractures. Optimal management of osteoporosis requires that clinicians identify patients who have or are at risk for osteoporosis and understand the appropriate use of the available treatment options. This activity summarizes the most important oral sessions from the 8th International Symposium on Osteoporosis (ISO): Translating Research into Clinical Practice, which took place in April 2009, and includes commentary from Susan L. Greenspan, MD, regarding the practical application of the session topics in day-to-day practice.
Target Audience
This activity has been designed to meet the educational needs of health care professionals in endocrinology, rheumatology, bone disease, obstetrics/gynecology, and primary care who manage patients who have or are at risk for osteoporosis.
Learning Objectives
Upon completion of this activity, participants should be able to:
- Evaluate the latest clinical safety and efficacy data for new therapeutic agents for osteoporosis
- Identify factors to consider in patient selection for osteoporosis therapies
- Assess specific risks for osteoporosis and osteoporosis-related fractures, including secondary causes
- Formulate patient management strategies based on individual risk for osteoporosis and osteoporosis-related fracture
Guest Editor
Susan L. Greenspan, MD
Professor of Medicine
Director, Osteoporosis Prevention and Treatment Center
University of Pittsburgh Medical School
Pittsburgh, Pennsylvania
Accreditation Statement/Credit Designation
Physician:
Curatio CME Institute is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
Curatio CME Institute designates this educational activity for a maximum of 1.0 AMA PRA Category 1 Credit ™. Physicians should only claim credit commensurate with the extent of their participation in the activity.
Nursing:
EduPro Resources LLC is an approved provider of continuing nursing education by NJSNA, an accredited approver by the American Nurses Credentialing Center (ANCC)’s Commission on Accreditation, Provider Number P208-8/08-11.
EduPro is also an approved provider by the California Board of Registered Nursing, Provider Number CEP-14387.
This activity is approved for 1.0 nursing contact hours.
Method of Participation
There are no fees for participating in this CME activity. To receive credit during the period July 2009 to July 30, 2010, participants must (1) read the learning objectives and disclosure statements, (2) study the entire educational activity, (3) complete the presurvey and postsurvey, and (4) complete the activity evaluation form.
The posttest can be accessed at the end of the activity. Please e-mail any questions to cmeinfo@curatiocme.com.
Media
A printed newsletter and the Internet were selected as the instructional formats to accommodate the learning preferences of a significant portion of our target audience.
Disclosure
In accordance with the ACCME and ANCC Standards for Commercial Support, all CME and CNE providers are required to disclose to the activity audience the relevant financial relationships of everyone in a position to control content of an educational activity. A relevant financial relationship is a relationship in any amount occurring in the last 12 months with a commercial interest whose products or services are discussed in the CME/CNE activity content over which the individual has control. Relationship information appears below:
Susan L. Greenspan, MD, has disclosed the following relevant financial relationships:
| Consultant | Merck |
| Research | Eli Lilly, Merck, Novartis, Procter & Gamble Pharmaceuticals, Sanofi-aventis |
| Speaker | Eli Lilly, Procter & Gamble Pharmaceuticals, Sanofi-aventis |
Curatio CME Institute
Shari J. Dermer, PhD, Medical Director, has disclosed no relevant financial relationships.
Thomas Finnegan, PhD, Medical Writer, has disclosed no relevant financial relationships.
Jonathan S. Simmons, ELS, Managing Editor, has disclosed no relevant financial relationships.
Derek Warnick, CME Director, has disclosed no relevant financial relationships.
EduPro Resources LLC
Dorothy Caputo, MA, APRN, BC-ADM, CDE, Nurse Planner, has disclosed no relevant financial relationships.
Disclaimer
The information presented in this activity is for continuing medical education purposes only and is not meant to substitute for the independent medical judgment of a physician regarding diagnosis and treatment of a specific patient's medical condition.
Accreditation refers to educational content only and does not imply ANCC, CBRN, or EduPro endorsement of any product or service.
Unapproved Product Use
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the US Food and Drug Administration. Curatio CME Institute, EduPro Resources, and Amgen do not recommend the use of any agent outside the labeled indications.
The opinions expressed in this educational activity are those of the faculty and do not necessarily represent the views of Curatio CME Institute, EduPro Resources LLC, or Amgen Inc. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.
| Generic Name | Trade Name | Approved Use (if any) | Unapproved/Investigational Use |
| Alendronate | Fosamax® |
|
Osteoporosis caused by androgen-deprivation therapy |
| Arzoxifene | N/A | N/A | Postmenopausal osteoporosis |
| Bazedoxifene | N/A | N/A | Postmenopausal osteoporosis |
| Denosumab | N/A | N/A | Postmenopausal osteoporosis; in combination with methotrexate for the treatment of rheumatoid arthritis |
| Etidronate | Didronel® | Treatment of symptomatic Paget's disease of bone and prevention and treatment of heterotopic ossification following total hip replacement or due to spinal cord injury | Glucocorticoid-induced osteoporosis |
| Lasofoxifene | N/A | N/A | Postmenopausal osteoporosis |
| Pamidronate | Aredia® |
|
Osteoporosis caused by androgen-deprivation therapy |
| Raloxifene | Evista® |
|
Osteoporosis caused by androgen-deprivation therapy |
| Risedronate | Actonel® |
|
Chemotherapy-induced bone loss in breast cancer patients |
| Teriparatide | Forteo® |
|
Postmenopausal women with mild to moderate chronic kidney disease; glucocorticoid-induced osteoporosis |
| Toremifene | Fareston® | Treatment of metastatic breast cancer in postmenopausal women with estrogen-receptor positive or unknown tumors | Osteoporosis caused by androgen-deprivation therapy |
| Zoledronic acid | Reclast® |
|
In combination with methotrexate for the treatment of rheumatoid arthritis; chemotherapy-induced bone loss in breast cancer patients |
Hardware/Software Requirements
- Javascript-enabled browser
- Active Internet connection
- Adobe Acrobat Reader
- Adobe Flash Player plugin v.8.0+

Contact Information
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